We are interested in establishing direct correlations between the biochemical states and the conformations of molecular machinery while they are performing their tasks. Our main tools are cryo-electron microscopy (cryo-EM), which enables the structure determination of proteins and optical spectroscopy, which has the ability to detect and characterize ligands. To achieve our goals, we are developing strategies to combine the two techniques.
We focus our efforts on several scientifically and medically important molecular machines:
Membrane fusion machinery